APOE and Cerebral Small Vessel Disease Markers in Patients With Intracerebral Hemorrhage.

ABSTRACT:

Background and objective

We investigated the associations between the APOE genotype, intracerebral hemorrhage (ICH), and neuroimaging markers of cerebral amyloid angiopathy (CAA).

Methods

We included patients from a prospective, multicenter UK observational cohort study of patients with ICH and representative UK population controls. First, we assessed the association of the APOE genotype with ICH (compared with controls without ICH). Second, among patients with ICH, we assessed the association of APOE status with the hematoma location (lobar or deep) and brain CT markers of CAA (finger-like projections [FLP] and subarachnoid extension [SAE]).

Results

We included 907 patients with ICH and 2,636 controls. The mean age was 73.2 (12.4 SD) years for IC

SUBMITTER: Hostettler IC 

PROVIDER: S-EPMC9576291 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature