Distinct responses of newly identified monocyte subsets to advanced gastrointestinal cancer and COVID-19.

ABSTRACT: Monocytes are critical cells of the immune system but their role as effectors is relatively poorly understood, as they have long been considered only as precursors of tissue macrophages or dendritic cells. Moreover, it is known that this cell type is heterogeneous, but our understanding of this aspect is limited to the broad classification in classical/intermediate/non-classical monocytes, commonly based on their expression of only two markers, i.e. CD14 and CD16. We deeply dissected the heterogeneity of human circulating monocytes in healthy donors by transcriptomic analysis at single-cell level and identified 9 distinct monocyte populations characterized each by a profile suggestive of specialized functions. The classical monocyte subset in fact included five distinct populations, each e

SUBMITTER: Rigamonti A 

PROVIDER: S-EPMC9576306 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature