Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition

ABSTRACT:

Background

Diabetes mellitus brings serious threats and financial burdens to human beings worldwide. Fufang Fanshiliu decoction (FFSLD), a traditional Chinese medicine formula showing great antidiabetic effects, has been used in clinics for many years.

Objective

This study aims to explore the underlying therapeutic mechanisms of FFSLD in Type II diabetes mellitus (T2DM).

Methods

Sprague–Dawley rats induced by high-fat diet feeding combined with streptozotocin injection were used to establish the T2DM model. All rats were randomly divided into 6 groups: control, model, metformin, high dosage, middle dosage, and low dosage of FFSLD. After 4 weeks of treatment, serum, intestinal mucosa, and fecal samples were collected for further analysis. ELISA was used to dete

SUBMITTER: Li L 

PROVIDER: S-EPMC9576391 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature