TMP195 Exerts Antitumor Effects on Colorectal Cancer by Promoting M1 Macrophages Polarization

ABSTRACT: Studies have shown that epigenetic enzymes such as histone deacetylase (HDAC) are closely related to cancers and that several HDAC inhibitors exert antitumor effects. Studies have further suggested that class IIa HDAC inhibitors are related to immune functions, including immune responses and the expression of chemokines and complement pathway components. TMP195, a selective class IIa HDAC inhibitor, has been reported to be effective against breast cancer. However, the role and mechanism of TMP195 in colorectal cancer remain unknown. In this study, we found that TMP195 significantly reduced the tumor burden in two mouse models of colitis-associated colorectal cancer (CAC) and subcutaneous tumor. Mechanistically, TMP195 decreased the proportion of total macrophages but increased the proporti

SUBMITTER: Han Y 

PROVIDER: S-EPMC9576521 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature