Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense.

ABSTRACT: Human African trypanosomiasis (HAT) is a neglected tropical disease that is caused by flagellated parasites of the genus Trypanosoma. HAT imposes a significant socio-economic burden on many countries in sub-Saharan Africa and its control is hampered by several drawbacks ranging from the ineffectiveness of drugs, complex dosing regimens, drug resistance, and lack of a vaccine. Despite more than a century of research and investigations, the development of a vaccine to tackle HAT is still challenging due to the complex biology of the pathogens. Advancements in computational modeling coupled with the availability of an unprecedented amount of omics data from different organisms have allowed the design of new generation vaccines that offer better antigenicity and safety profile. One of s

SUBMITTER: Danazumi AU 

PROVIDER: S-EPMC9576565 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature