A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies.

ABSTRACT: Rationale: The blood-brain barrier (BBB) is a major impediment to therapeutic intracranial drug delivery for the treatment of neurodegenerative diseases, including Alzheimer's disease (AD). Focused ultrasound applied together with microbubbles (FUS^+MB) is a novel technique to transiently open the BBB and increase drug delivery. Evidence suggests that FUS^+MB is safe, however, the effects of FUS^+MB on human BBB cells, especially in the context of AD, remain sparsely investigated. In addition, there currently are no cell platforms to test for FUS^+MB-mediated drug delivery. Methods: Here we generated BBB cells (induced brain endothelial-like cells (iBECs) and astrocytes (iAstrocytes)) from apolipoprotein E gene allele E4 (APOE4,

SUBMITTER: Wasielewska JM 

PROVIDER: S-EPMC9576609 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature