Obesity-related biomarkers underlie a shared genetic architecture between childhood body mass index and childhood asthma.

ABSTRACT: Obesity and asthma are both common diseases with high population burden worldwide. Recent genetic association studies have shown that obesity is associated with asthma in adults. The relationship between childhood obesity and childhood asthma, and the underlying mechanisms linking obesity to asthma remain to be clarified. In the present study, leveraging large-scale genetic data from UK biobank and several other data sources, we investigated the shared genetic components between body mass index (BMI, n = 39620) in children and childhood asthma (n_case = 10524, n_control = 373393). We included GWAS summary statistics for nine obesity-related biomarkers to evaluate potential biological mediators underlying obesity and asthma. We found a genetic correlation (Rg = 0.10, P =

SUBMITTER: Han X 

PROVIDER: S-EPMC9576683 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature