Brain milieu induces early microglial maturation through the BAX-Notch axis.

ABSTRACT: Microglia are derived from primitive myeloid cells and gain their early identity in the embryonic brains. However, the mechanism by which the brain milieu confers microglial maturation signature remains elusive. Here, we demonstrate that the bax^cq55 zebrafish and Bax^tm1Sjk mouse embryos exhibit similarly defective early microglial maturation. BAX, a typical pro-apoptotic factor, is highly enriched in neuronal cells and regulates microglial maturation through both pro-apoptotic and non-apoptotic mechanisms. BAX regulates dlb via the CaMKII-CREB axis calcium-dependently in living neurons while ensuring the efficient Notch activation in the immigrated pre-microglia by apoptotic neurons. Notch signaling is conserved in supporting embryonic microglia maturation. Compromise

SUBMITTER: Zhao F 

PROVIDER: S-EPMC9576735 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature