Reconstruction of ovine axonal cytoarchitecture enables more accurate models of brain biomechanics

ABSTRACT: There is an increased need and focus to understand how local brain microstructure affects the transport of drug molecules directly administered to the brain tissue, for example in convection-enhanced delivery procedures. This study reports a systematic attempt to characterize the cytoarchitecture of commissural, long association and projection fibres, namely the corpus callosum, the fornix and the corona radiata, with the specific aim to map different regions of the tissue and provide essential information for the development of accurate models of brain biomechanics. Ovine samples are imaged using scanning electron microscopy combined with focused ion beam milling to generate 3D volume reconstructions of the tissue at subcellular spatial resolution. Focus is placed on the characteristic cy

SUBMITTER: Bernardini A 

PROVIDER: S-EPMC9576772 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature