No evidence for intervention-associated DNA methylation changes in monocytes of patients with posttraumatic stress disorder.

ABSTRACT: DNA methylation patterns can be responsive to environmental influences. This observation has sparked interest in the potential for psychological interventions to influence epigenetic processes. Recent studies have observed correlations between DNA methylation changes and therapy outcome. However, most did not control for changes in cell composition. This study had two aims: first, we sought to replicate therapy-associated changes in DNA methylation of commonly assessed candidate genes in isolated monocytes from 60 female patients with post-traumatic stress disorder (PTSD). Our second, exploratory goal was to identify novel genomic regions with substantial pre-to-post intervention DNA methylation changes by performing whole-genome bisulfite sequencing (WGBS) in two patients with PTSD. Equiv

SUBMITTER: Hummel E 

PROVIDER: S-EPMC9576776 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature