Immune Responses and Risk of Triple-negative Breast Cancer: Implications for Higher Rates among African American Women.

ABSTRACT: The etiology of triple-negative breast cancers (TNBC) is poorly understood. As many TNBCs develop prior to the initiation of breast cancer screening or at younger ages when the sensitivity of mammography is comparatively low, understanding the etiology of TNBCs is critical for discovering novel prevention approaches for these tumors. Furthermore, the higher incidence rate of estrogen receptor-negative breast cancers, and specifically, of TNBCs, among young African American women (AAW) versus white women is a source of racial disparities in breast cancer mortality. Whereas immune responses to TNBCs have received considerable attention in relation to prognosis and treatment, the concept that dysregulated immune responses may predispose to the development of TNBCs has received limited attenti

SUBMITTER: Ogony JW 

PROVIDER: S-EPMC9576802 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature