Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit: a narrative review.

ABSTRACT: Patients with acute pancreatitis (AP) often require ICU admission, especially when signs of multiorgan failure are present, a condition that defines AP as severe. This disease is characterized by a massive pancreatic release of pro-inflammatory cytokines that causes a systemic inflammatory response syndrome and a profound intravascular fluid loss. This leads to a mixed hypovolemic and distributive shock and ultimately to multiorgan failure. Aggressive fluid resuscitation is traditionally considered the mainstay treatment of AP. In fact, all available guidelines underline the importance of fluid therapy, particularly in the first 24-48 h after disease onset. However, there is currently no consensus neither about the type, nor about the optimal fluid rate, total volume, or goal of fluid admi

SUBMITTER: Crosignani A 

PROVIDER: S-EPMC9576837 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature