Prognostic value of cuproptosis-related genes signature and its impact on the reshaped immune microenvironment of glioma.

ABSTRACT: Glioma is the most prevalent malignancy in the central nervous system. The impact of ion-induced cell death on malignant tumors' development and immune microenvironment has attracted broad attention in recent years. Cuproptosis is a novel copper-dependent mechanism that could potentially regulate tumor cell death by targeting mitochondria respiration. However, the role of cuproptosis in gliomas remains unclear. In the present study, we investigated the relationships between the expression of cuproptosis-related genes (CRGs) and tumor characteristics, including prognosis and microenvironment of glioma, by analyzing multiple public databases and our cohort. Consensus clustering based on the expression of twelve CRGs stratified the glioma patients into three subgroups with significantly diffe

SUBMITTER: Chen S 

PROVIDER: S-EPMC9576857 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature