A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4⁺ T lymphocytes in unexposed individuals.

ABSTRACT: Circulating, blood-borne SARS-CoV-2-reactive memory T cells in persons so far unexposed to SARS-CoV-2 or the vaccines have been described in 20-100% of the adult population. They are credited with determining the efficacy of the immune response in COVID-19. Here, we demonstrate the presence of preexisting memory CD4⁺ T cells reacting to peptides of the spike, membrane, or nucleocapsid proteins of SARS-CoV-2 in the bone marrow of all 17 persons investigated that had previously not been exposed to SARS-CoV-2 or one of the vaccines targeting it, with only 15 of these persons also having such cells detectable circulating in the blood. The preexisting SARS-CoV-2-reactive memory CD4⁺ T cells of the bone marrow are abundant and polyfunctional, with the phenotype of central m

SUBMITTER: Li J 

PROVIDER: S-EPMC9576920 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature