Probing predilection to Crohn's disease and Crohn's disease flares: A crowd-sourced bioinformatics approach

ABSTRACT:

Background

Crohn's Disease (CD) is an inflammatory disease of the gastrointestinal tract that affects millions of patients. While great strides have been made in treatment, namely in biologic therapy such as anti-TNF drugs, CD remains a significant health burden.

Method

We conducted two meta-analyses using our STARGEO platform to tag samples from Gene Expression Omnibus. One analysis compares inactive colonic biopsies from CD patients to colonic biopsies from healthy patients as a control and the other compares colonic biopsies from active CD lesions to inactive lesions. Separate tags were created to tag colonic samples from inflamed biopsies (total of 65 samples) and quiescent tissue in CD patients (total of 39 samples), and healthy tissue from non-CD patients (total of

SUBMITTER: Aljabban J 

PROVIDER: S-EPMC9576970 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature