All-in-focus fine needle aspiration biopsy imaging based on Fourier ptychographic microscopy

ABSTRACT:

Context

Cytology is the study of whole cells in diagnostic pathology. Unlike standard histologic thinly sliced specimens, cytologic preparations consist of preparations of whole cells where cells commonly cluster and aggregate. As such, cytology preparations are generally much thicker than histologic slides, resulting in large patches of defocus when examined under the microscope. A diagnostic aggregate of cells often cannot be viewed in focus together, requiring pathologists to continually manipulate the focal plane, complicating the task of accurately assessing the entire cellular aggregate and thus in making a diagnosis. Further, it is extremely difficult to acquire useful uniformly in-focus digital images of cytology preparations for applications such as remote diagnostic eval

SUBMITTER: Liang M 

PROVIDER: S-EPMC9577034 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature