Iron deprivation enhances transcriptional responses to in vitro growth arrest of Mycobacterium tuberculosis.

ABSTRACT: The establishment of Mycobacterium tuberculosis (Mtb) long-term infection in vivo depends on several factors, one of which is the availability of key nutrients such as iron (Fe). The relation between Fe deprivation inside and outside the granuloma, and the capacity of Mtb to accumulate lipids and persist in the absence of growth is not well understood. In this context, current knowledge of how Mtb modifies its lipid composition in response to growth arrest, depending on iron availability, is scarce. To shed light on these matters, in this work we compare genome-wide transcriptomic and lipidomic profiles of Mtb at exponential and stationary growth phases using cultures with glycerol as a carbon source, in the presence or absence of iron. As a result, we found that transcriptom

SUBMITTER: Alebouyeh S 

PROVIDER: S-EPMC9577196 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature