CD38⁺CD39⁺ NK cells associate with HIV disease progression and negatively regulate T cell proliferation.

ABSTRACT: The ectonucleotidases CD38 and CD39 have a critical regulatory effect on tumors and viral infections via the adenosine axis. Natural killer (NK) cells produce cytokines, induce cytotoxic responses against viral infection, and acquire immunoregulatory properties. However, the roles of CD38 and CD39 expressed NK cells in HIV disease require elucidation. Our study showed that the proportions of CD38⁺CD39⁺ NK cells in HIV-infected individuals were positively associated with HIV viral loads and negatively associated with the CD4⁺ T cell count. Furthermore, CD38⁺CD39⁺ NK cells expressed additional inhibitory receptors, TIM-3 and LAG-3, and produced more TGF-β. Moreover, autologous NK cells suppressed the proliferation of CD8⁺

SUBMITTER: Qian S 

PROVIDER: S-EPMC9577302 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature