Abnormal cortical morphology in children and adolescents with intermittent exotropia.

ABSTRACT:

Purpose

To investigate cortical differences, age-related cortical differences, and structural covariance differences between children with intermittent exotropia (IXT) and healthy controls (HCs) using high-resolution magnetic resonance imaging (MRI).

Methods

Sixteen IXT patients and 16 HCs underwent MRI using a 3-T MR scanner. FreeSurfer software was used to obtain measures of cortical volume, thickness, and surface area. Group differences in cortical thickness, volume and surface area were examined using a general linear model with intracranial volume (ICV), age and sex as covariates. Then, the age-related cortical differences between the two groups and structural covariance in abnormal morphometric changes were examined.

Results

Compared to HCs, IXT patients demonst

SUBMITTER: Wang X 

PROVIDER: S-EPMC9577327 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature