Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence

ABSTRACT: Social isolation during the juvenile stage results in structural and functional impairment of the brain and deviant adult aggression. However, the specific subregions and cell types that underpin this deviant behavior are still largely unknown. Here, we found that adolescent social isolation led to a shortened latency to attack onset and extended the average attack time, accompanied by anxiety-like behavior and deficits in social preference in adult mice. However, when exposed to social isolation during adulthood, the mice did not show these phenotypes. We also found that the structural plasticity of prefrontal pyramidal neurons, including the dendritic complexity and spine ratio, was impaired in mice exposed to adolescent social isolation. The parvalbumin (PV) interneurons in the prefront

SUBMITTER: Li X 

PROVIDER: S-EPMC9577330 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature