Prefrontal feature representations drive memory recall.

ABSTRACT: Memory formation involves binding of contextual features into a unitary representation^1-4, whereas memory recall can occur using partial combinations of these contextual features. The neural basis underlying the relationship between a contextual memory and its constituent features is not well understood; in particular, where features are represented in the brain and how they drive recall. Here, to gain insight into this question, we developed a behavioural task in which mice use features to recall an associated contextual memory. We performed longitudinal imaging in hippocampus as mice performed this task and identified robust representations of global context but not of individual features. To identify putative brain regions that provide feature inputs to hippocampus, we inhibi

SUBMITTER: Yadav N 

PROVIDER: S-EPMC9577479 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature