Identifying and revealing different brain neural activities of cognitive subtypes in early course schizophrenia.

ABSTRACT:

Background

Cognitive subtypes of schizophrenia may exhibit different neurobiological characteristics. This study aimed to reveal the underlying neurobiological features between cognitive subtypes in the early course of schizophrenia (ECS). According to prior studies, we hypothesized to identify 2-4 distinct cognitive subtypes. We further hypothesized that the subtype with relatively poorer cognitive function might have lower brain spontaneous neural activity than the subtype with relatively better cognitive function.

Method

Cognitive function was assessed by the MATRICS Consensus Cognitive Battery (MCCB). Resting-state functional magnetic resonance imaging scanning was conducted for each individual. There were 155 ECS individuals and 97 healthy controls (HCs) included in the

SUBMITTER: Shao T 

PROVIDER: S-EPMC9577612 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature