Knowledge-based planning for multi-isocenter VMAT total marrow irradiation.

ABSTRACT:

Purpose

Total marrow irradiation (TMI) involves optimization of extremely large target volumes and requires extensive clinical experience and time for both treatment planning and delivery. Although volumetric modulated arc therapy (VMAT) achieves substantial reduction in treatment delivery time, planning process still presents a challenge due to use of multiple isocenters and multiple overlapping arcs. We developed and evaluated a knowledge-based planning (KBP) model for VMAT-TMI to address these clinical challenges.

Methods

Fifty-one patients previously treated in our clinic were selected for the model training, while 22 patients from another clinic were used as a test set. All plans used a 3-isocenter to cover sub-target volumes of head and neck (HN), chest, and pelvis. Ch

SUBMITTER: Ahn KH 

PROVIDER: S-EPMC9577613 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature