High HDAC5 expression correlates with a poor prognosis and the tumor immune microenvironment in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignant tumors worldwide and has a poor prognosis. Previous studies have confirmed differential histone deacetylase 5 (HDAC5) expression in various common tumors. HDAC5 is also associated with prognosis and plays a role in cancer cell proliferation, invasion, and metastasis, as well as the tumor immune microenvironment (TIME). However, HDAC5 in GC is not well understood. The aims of study were to investigate the HDAC5 expression correlates with prognosis and the TIME in GC.

Methods

A total of 355 tumor tissues and 300 matched paracancerous tissues were collected from GC patients who underwent radical surgery. The correlation between clinicopathological characteristics, immune-related facto

SUBMITTER: Yuan L 

PROVIDER: S-EPMC9577731 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature