Adeno-associated virus vector-mediated gene therapy for the treatment of ovarian cancer: a literature review.

ABSTRACT:

Background and objective

The adeno-associated virus (AAV) is a member of the Parvoviridae family and has emerged as one of the most popular and promising approaches for gene therapy due to its low toxicity, low immunogenicity, and excellent safety after optimization. Advances in gene therapy methods have allowed novel treatments such as using AAV to knock out or repair target genes. AAV-mediated gene therapy has been used in numerous tumor studies, including lymphatic metastasis of prostate cancer, liver cancer, and renal cell carcinoma in mice. Ovarian cancer is an extremely aggressive malignancy which is prone to recurrence, and AAV vector-based gene therapy may be a potential treatment strategy.

Methods

Herein, we reviewed the current research to provide an update on the

SUBMITTER: Zhu J 

PROVIDER: S-EPMC9577757 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature