Frailty index and risk of cardiovascular diseases: a mendelian randomization study.

ABSTRACT:

Background

Previous epidemiological evidence has suggested that frailty status might be associated with cardiovascular diseases (CVDs). However, the exact causality remains unestablished. In this study, we employed Mendelian randomization and sought to investigate the potential causality in association of frailty index (FI) with cardiovascular outcomes [coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF)].

Methods

Independent single nucleotide polymorphisms (SNPs) at genome-wide significance for FI were obtained from a recent genome-wide association study (GWAS) meta-analysis of European descent (n=175,226). The association of these SNPs with CVDs was examined in summary statistics from corresponding GWASs of European d

SUBMITTER: Li J 

PROVIDER: S-EPMC9577775 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature