Circular RNA profile in Graves' disease and potential function of hsa_circ_0090364.

ABSTRACT:

Background

Graves' disease is a common autoimmune disease. Cytokines and their signalling pathways play a major part in the pathogenesis of Graves' disease; however, the underlying mechanism needs to be clarified.

Aims

The aim of this study was to explore whether circular RNAs participate in the immunological pathology of Graves' disease via cytokine-related signalling pathways.

Methods

Bioinformatics analysis was performed to identify differentially expressed circular RNAs and their targets and associated pathways. A total of three patients with Graves' disease and three sex- and age-matched healthy controls were enrolled for validation with microarray analysis and real-time quantitative PCR (qPCR). An additional 24 patients with Graves' disease and 24 gender- and ag

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC9578071 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature