Impact of gender-affirming treatment on bone health in transgender and gender diverse youth.

ABSTRACT: Both in the United States and Europe, the number of minors who present at transgender healthcare services before the onset of puberty is rapidly expanding. Many of those who will have persistent gender dysphoria at the onset of puberty will pursue long-term puberty suppression before reaching the appropriate age to start using gender-affirming hormones. Exposure to pubertal sex steroids is thus significantly deferred in these individuals. Puberty is a critical period for bone development: increasing concentrations of estrogens and androgens (directly or after aromatization to estrogens) promote progressive bone growth and mineralization and induce sexually dimorphic skeletal changes. As a consequence, safety concerns regarding bone development and increased future fracture risk in transgen

SUBMITTER: Ciancia S 

PROVIDER: S-EPMC9578106 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature