Carboxylesterase 1d Inactivation Augments Lung Inflammation in Mice.

ABSTRACT: Carboxylesterases are members of the serine hydrolase superfamily and metabolize drugs, pesticides, and lipids. Previous research showed that inhibition of carboxylesterase 1 (CES1) in human macrophages altered the immunomodulatory effects of lipid mediators called prostaglandin glyceryl esters, which are produced by cyclooxygenase-catalyzed oxygenation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Ces1d - the mouse ortholog of human CES1 - is the most abundant Ces isoform in murine lung tissues and alveolar macrophages and a major target of organophosphate poisons. Monoacylglycerol lipase (Magl) is also expressed in murine lung and is the main enzyme responsible for 2-AG catabolism. Several metabolic benefits are observed in Ces1d^-/- mice fed a high-fat diet; thus, we w

SUBMITTER: Szafran BN 

PROVIDER: S-EPMC9578131 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature