Pregnancy-Related Tuberculous Meningitis and Immune Reconstitution Inflammatory Syndrome: A Case Series and Systematic Review

ABSTRACT: Abstract

Background

Tuberculosis is a leading cause of death among women of reproductive age. However, tuberculous meningitis, the most severe form of extrapulmonary tuberculosis, is rarely discussed in pregnancy despite this being a unique period of immune modulation that may predispose women to active disease.

Methods

We identified and described cases of tuberculous meningitis among pregnant or postpartum women screened during meningitis clinical trials in Uganda from 2018 to 2022. We conducted a systematic literature review via PubMed/Medline and Embase for all English-language publications from 1970 to 10 July 2022, to identify additional cases.

Results

We identified 8 cases of pregnancy-related tuberculous meningitis in Ugandan women living with human immuno

SUBMITTER:  

PROVIDER: S-EPMC9578166 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature