Individualizing mechanical ventilation: titration of driving pressure to pulmonary elastance through Young's modulus in an acute respiratory distress syndrome animal model.

ABSTRACT:

Background

Mechanical ventilation increases the risk of lung injury (VILI). Some authors propose that the way to reduce VILI is to find the threshold of driving pressure below which VILI is minimized. In this study, we propose a method to titrate the driving pressure to pulmonary elastance in an acute respiratory distress syndrome model using Young's modulus and its consequences on ventilatory-induced lung injury.

Material and methods

20 Wistar Han male rats were used. After generating an acute respiratory distress syndrome, two groups were studied: (a) standard protective mechanical ventilation: 10 rats received 150 min of mechanical ventilation with driving pressure = 14 cm H₂O, tidal volume < 6 mL/kg) and (b) individualized mechanical ventilation: 10 rats recei

SUBMITTER: Mingote A 

PROVIDER: S-EPMC9578179 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature