Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness.

ABSTRACT:

Background

Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive. We have previously shown that NRAS is highly expressed selectively in basal-like subtypes of invasive breast cancers and can promote their growth and progression. In this study, we investigated whether NRAS expression at the DCIS stage can control transition from luminal DCIS to basal-like invasive breast cancers.

Methods

Wilcoxon rank-sum test was performed to assess expression of NRAS in DCIS compared to invasive breast tumors in patients. NRAS mRNA levels were also determined by fluorescence in situ hybridization in patient tumor microarrays (TMAs) with concurren

SUBMITTER: Zheng ZY 

PROVIDER: S-EPMC9578182 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature