Atlas of human dental pulp cells at multiple spatial and temporal levels based on single-cell sequencing analysis.

ABSTRACT: The dental pulp plays a crucial role in the long-term maintenance of tooth function. The progress of endodontic treatment and pulp tissue regeneration engineering has made pulp-regeneration therapy promising in clinical practice. However, the mechanisms of pulp regeneration and the role of dental stem cells in development and regeneration have not been fully elucidated. Bridging the gaps between clinical operation and basic research is urgently needed. With the application of single-cell sequencing technology in dental research, the landscapes of human dental pulp cells have begun being outlined. However, the specific cellular heterogeneity of dental pulp cells, especially that of dental stem cells, at different spatial and temporal levels, is still unclear. In this study, we used single-c

SUBMITTER: Ren H 

PROVIDER: S-EPMC9578252 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature