Distribution of microbiota in cervical preneoplasia of racially disparate populations.

ABSTRACT:

Backgrounds

Microbiome dysbiosis is an important contributing factor in tumor development and thus may be a risk predictor for human malignancies. In the United States, women with Hispanic/Latina (HIS) and African American (AA) background have a higher incidence of cervical cancer and poorer outcomes than Caucasian American (CA) women.

Methods

Here, we assessed the distribution pattern of microbiota in cervical intraepithelial neoplasia (CIN) lesions obtained from HIS (n = 12), AA (n = 12), and CA (n = 12) women, who were screened for CC risk assessment. We employed a 16S rRNA gene sequencing approach adapted from the NIH-Human Microbiome Project to identify the microbial niche in all CIN lesions (n = 36).

Results

We detected an appreciably decreased abundance of bene

SUBMITTER: Vikramdeo KS 

PROVIDER: S-EPMC9578267 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature