Inhibition of Staphylococcus aureus biofilm formation by gurmarin, a plant-derived cyclic peptide.

ABSTRACT: Staphylococcus aureus (Sa) is an opportunistic pathogen capable of causing various infections ranging from superficial skin infections to life-threatening severe diseases including pneumonia and sepsis. Sa produces biofilms readily on biotic and abiotic surfaces. Biofilm cells are embedded in a protective polysaccharide matrix and show an innate resistance to antibiotics, disinfectants, and clearance by host defenses. Additionally, biofilms serve as a source for systemic dissemination. Moreover, infections associated with biofilms may result in longer hospitalizations, a need for surgery, and may even result in death. Agents that inhibit the formation of biofilms and virulence without affecting bacterial growth to avoid the development of drug resistance could be useful for t

SUBMITTER: Chang AW 

PROVIDER: S-EPMC9578378 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature