Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium.

ABSTRACT: Frequent outbreaks of Salmonella Typhimurium infection, in both animal and human populations and with the potential for zoonotic transmission, pose a significant threat to the public health sector. The rapid emergence and spread of more invasive multidrug-resistant clinical isolates of Salmonella further highlight the need for the development of new drugs with effective broad-spectrum bactericidal activities. The synthesis and evaluation of main-chain cationic polyimidazolium 1 (PIM1) against several Gram-positive and Gram-negative bacteria have previously demonstrated the efficacy profile of PIM1. The present study focuses on the antibacterial and anti-biofilm activities of PIM1 against Salmonella in both in vitro and in ovo settings. In vitro, PIM1 exhibited bacteric

SUBMITTER: Mon KKZ 

PROVIDER: S-EPMC9578408 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature