Exploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis.

ABSTRACT: Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not well understood. To address this issue, functional, transcriptomic, and metabolomic analyses were performed on C. albicans cells subjected to temperature and serum induction in the presence or absence of E2. Increased filament formation was observed in E2 treated cells. Surprisingly, cells treated with a combination of E2 and serum showed decreased filament formation. Furthermore, the transcriptomic analysis revealed that serum and E2 treatment is associated with downregulated expression of

SUBMITTER: Bataineh MTA 

PROVIDER: S-EPMC9578540 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature