DSCN: Double-target selection guided by CRISPR screening and network.

ABSTRACT: Cancer is a complex disease with usually multiple disease mechanisms. Target combination is a better strategy than a single target in developing cancer therapies. However, target combinations are generally more difficult to be predicted. Current CRISPR-cas9 technology enables genome-wide screening for potential targets, but only a handful of genes have been screend as target combinations. Thus, an effective computational approach for selecting candidate target combinations is highly desirable. Selected target combinations also need to be translational between cell lines and cancer patients. We have therefore developed DSCN (double-target selection guided by CRISPR screening and network), a method that matches expression levels in patients and gene essentialities in cell lines through spect

SUBMITTER: Liu E 

PROVIDER: S-EPMC9578612 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature