Transgenerational effects of alcohol on behavioral sensitivity to alcohol in Caenorhabditis elegans.

ABSTRACT: Alcohol abuse and dependence have a substantial heritable component. Although the genome has been considered the sole vehicle of heritable phenotypes, recent studies suggest that drug or alcohol exposure may induce alterations in gene expression that are transmitted across generations. Still, the transgenerational impact of alcohol use (and abuse) remains largely unexplored in part because multigenerational studies using rodent models present challenges for time, sample size, and genetic heterogeneity. Here, we took advantage of the extremely short generation time, large broods, and clonal form of reproduction of the nematode Caenorhabditis elegans. We developed a model of pre-fertilization parental alcohol exposure to test alterations in behavioral responses to acute alcohol treatment (re

SUBMITTER: Guzman DM 

PROVIDER: S-EPMC9578632 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature