Calcium and activity-dependent signaling in the developing cerebral cortex.

ABSTRACT: Calcium influx can be stimulated by various intra- and extracellular signals to set coordinated gene expression programs into motion. As such, the precise regulation of intracellular calcium represents a nexus between environmental cues and intrinsic genetic programs. Mounting genetic evidence points to a role for the deregulation of intracellular calcium signaling in neuropsychiatric disorders of developmental origin. These findings have prompted renewed enthusiasm for understanding the roles of calcium during normal and dysfunctional prenatal development. In this Review, we describe the fundamental mechanisms through which calcium is spatiotemporally regulated and directs early neurodevelopmental events. We also discuss unanswered questions about intracellular calcium regulation during t

SUBMITTER: Arjun McKinney A 

PROVIDER: S-EPMC9578689 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature