Ginsenoside Rg1 Reduces Oxidative Stress Via Nrf2 Activation to Regulate Age-Related Mesenchymal Stem Cells Fate Switch Between Osteoblasts and Adipocytes.

ABSTRACT:

Background

An important feature of aging cells is the gradual loss of physiological integrity. As aging progresses, MSCs change preferring to differentiate toward adipocytes rather than osteoblasts. Oxidative stress accumulation is an important factor in age-related bone loss. Many experiments have demonstrated the good therapeutic effect of Ginsenoside (Rg1) on oxidative stress injury. In this study, we investigated the effect of Rg1 on the osteogenic-adipogenic differentiation balance of bone marrow mesenchymal stem cells (BMMSC).

Objective

To analyze the potential application value of Rg1 in the treatment of senile osteoporosis.

Methods

BMMSCs were isolated from healthy donors of different ages and identified based on isotype and by multi-differentiation induction.

SUBMITTER: Hou J 

PROVIDER: S-EPMC9578818 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature