Cytotoxicity of Hybrid Noble Metal-Polymer Composites.

ABSTRACT: The aim of the present research was to assess the cytotoxicity of gold and silver nanoparticles synthesized into dextran-graft-polyacrylamide (D-PAA) polymer nanocarrier, which were used as a basis for further preparation of multicomponent nanocomposites revealed high efficacy for antitumor therapy. The evaluation of the influence of Me-polymer systems on the viability and metabolic activity of fibroblasts and eryptosis elucidating the mechanisms of the proeryptotic effects has been done in the current research. The nanocomposites investigated in this study did not reduce the survival of fibroblasts even at the highest used concentration. Our findings suggest that hybrid Ag/D-PAA composite activated eryptosis via ROS- and Ca²⁺-mediated pathways at the low concentration, in contr

SUBMITTER: Tkachenko A 

PROVIDER: S-EPMC9578826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature