Construction and Validation of a Prognostic Model Based on mRNAsi-Related Genes in Breast Cancer.

ABSTRACT:

Background

Breast cancer is a big threat to the women across the world with substantial morbidity and mortality. The pressing matter of our study is to establish a prognostic gene model for breast cancer based on mRNAsi for predicting patient's prognostic survival.

Methods

From The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we downloaded the expression profiles of genes in breast cancer. On the basis of one-class logistic regression (OCLR) machine learning algorithm, mRNAsi of samples was calculated. Kaplan-Meier (K-M) and Kruskal-Wallis (K-W) tests were utilized for the assessment of the connection between mRNAsi and clinicopathological variables of the samples. As for the analysis on the correlation between mRNAsi and immune infiltration, ESTIM

SUBMITTER: Zhao X 

PROVIDER: S-EPMC9578885 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature