Ontology highlight
ABSTRACT:
SUBMITTER: Torres MJ
PROVIDER: S-EPMC9579017 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Torres Maria J MJ Zhang Xu X Slentz Dorothy H DH Koves Timothy R TR Patel Hailee H Truskey George A GA Muoio Deborah M DM
iScience 20220928 10
Two prominent frontline breast cancer (BC) chemotherapies commonly used in combination, doxorubicin (DOX) and docetaxel (TAX), are associated with long-lasting cardiometabolic and musculoskeletal side effects. Whereas DOX has been linked to mitochondrial dysfunction, mechanisms underlying TAX-induced myotoxicities remain uncertain. Here, the metabolic and functional consequences of TAX ± DOX were investigated using a 3D-bioengineered model of adult human muscle and a drug dosing regimen designed ...[more]