Cooperative assembly of filopodia by the formin FMNL2 and I-BAR domain protein IRTKS.

ABSTRACT: Filopodia are long finger-like actin-based structures that project out from the plasma membrane as cells navigate and explore their extracellular environment. The initiation of filopodia formation requires release of tension at the plasma membrane followed by the coordinated assembly of long unbranched actin filaments. Filopodia growth is maintained by a tip complex that promotes actin polymerization and protects the growing barbed ends of the actin fibers from capping proteins. Filopodia growth also depends on additional F-actin bundling proteins to stiffen the actin filaments as well as extension of the membrane sheath projecting from the cell periphery. These activities can be provided by a number of actin-binding and membrane-binding proteins including formins such as formin-like 2 (FM

SUBMITTER: Fox S 

PROVIDER: S-EPMC9579038 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature