Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma.

ABSTRACT: Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Here we show single-cell transcriptomics and functional analyses of the myeloid cell lineage in patients with non-medullary thyroid carcinoma (TC) and multinodular goiter, before and after treatment with radioactive iodine compared to healthy controls. Integrative data analysis indicates that monocytes of TC patients have transcriptional upregulation of antigen presentation, reduced cytokine production capacity, and overproduction of reactive oxygen species. Interestingly, these cancer-related pathological changes are partially removed upon treatment. In bone marrow, TC patients tend to

SUBMITTER: Rabold K 

PROVIDER: S-EPMC9579179 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature