Total synthesis of antiviral drug, nirmatrelvir (PF-07321332).

ABSTRACT: The emergence and rapid spread of coronavirus disease 2019 (COVID-19), a potentially fatal disease, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has swiftly led to public health crisis worldwide. Hence vaccines and antiviral therapeutics are an important part of the healthcare response to combat the ongoing threat by COVID-19. Here, we report an efficient synthesis of nirmatrelvir (PF-07321332), an orally active SARS-CoV-2 main protease inhibitor.

SUBMITTER: Shekhar C 

PROVIDER: S-EPMC9579207 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature