Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials.

ABSTRACT:

Purpose

Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (PCIBP) that include sensitization and sprouting of primary afferent sensory nerve fibres in bone. We also review current treatments and pain responses evoked by various treatment modalities in clinical trials in this patient population.

Methods

We reviewed the literature using PubMed to identify research on the pathobiology of PCIBP. Additionally, we reviewed clinical trials of various treatment modalities in patients with PCIBP with pain response outcomes published in the past 7 years.

Results

Recent clinical trials show that radionuclides, given either a

SUBMITTER: Smith AE 

PROVIDER: S-EPMC9579264 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature