Protective effect of nano-selenium on mercury-induced prehierarchical follicular atresia in laying hens.

ABSTRACT: This study investigated the effect of nano-selenium (nano-Se) in protecting laying hens from mercury (Hg)-induced prehierarchical follicular atresia. Furthermore, the endoplasmic reticulum stress (ERS) was explored to reveal the molecular mechanism. In vivo, 720 Hyline-Brown laying hens were treated with Hg and nano-Se alone or in combination. In vitro, the prehierarchical follicles were treated with Hg, nano-Se and 4-phenyl butyric acid (4-PBA) alone or in combination (Control, 25 μM Hg group, 10 μM nano-Se group, 20 μM nano-Se group, 25 μM Hg + 10 μM nano-Se group, 25 μM Hg + 20 μM nano-Se group, 25 μM Hg + 4-PBA group, and 25 μM Hg + 20 μM nano-Se + 4-PBA group). The GCs were treated with Hg and nano-Se alone or in combination (Control, 15 μM Hg group, 6 μM nano-Se group, 12 μM nano-Se

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9579407 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature