Ectopic foci do not co‐locate with ventricular epicardial stretch during early acute regional ischemia in isolated pig hearts

ABSTRACT: Abstract Ectopic activation during early acute regional ischemia may initiate fatal reentrant arrhythmias. However, the origin of this ectopy remains poorly understood. Studies suggest that systolic stretch arising from dyskinesia in ischemic tissue may cause ectopic depolarization due to cardiac mechanosensitivity. The aim of this study was to investigate the link between mechanical stretch and ectopic electrical activation during early acute regional ischemia. We used a recently developed optical mapping technique capable of simultaneous imaging of mechanical deformation and electrical activation in isolated hearts. Eight domestic swine hearts were prepared in left ventricular working mode (LVW), in which the left ventricle was loaded and contracting. In an additional eight non‐working (

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9579492 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature